VGF and early-onset autosomal dominant Alzheimer disease: The Vgf (non-acronymic) gene encodes a neuronal and neuroendocrine protein precursor [1] that is post-translationally processed with cell- and tissue-type specificity into multiple bioactive peptides that are secreted and are involved in numerous physio/pathological functions including reproduction [2], depression [3, 4], obesity [5], memory [6] and also neurodegenerative diseases, in particular Alzheimer’s disease (AD).