Interestingly, as part of the tauopathy study, Zheng and colleagues detected only 38 DEGs comparing C3aR1 KO to WT adult unfractionated hippocampus (FDR < 0.1, 29], whereas there were 4943 DEGs in our comparison of C3aR1 KO and WT primary microglia cultured from P0 cerebral cortex (FDR < 0.05), with only 4 overlapped with the 38 and which moved in opposite directions (personal communication). Here, C3AR1 is linked to tauopathy.