Collectively, the expression of NLRP3, caspase-1, GSDMD, and IL-1β protein was higher in cancer and atypical hyperplasia tissues than in benign endometrial tissues, significantly difference were observed in key pyroptotic protein caspase-1 and GSDMD (P < 0.05) (Table 1, Fig. 2). This evidence concerns the gene CASP1 and cancer.