There was also a trend of difference in NLRP3, caspase-1, and GSDMD protein between high and low/medium expression group in endometrial cancer related to survival rate, but there were different statistical differences between the research institutes (http://ualcan.path.uab.edu/analysis.html) (Additional file 3) [33, 34]. This evidence concerns the gene NLRP3 and endometrial cancer.