We stained human endometrial tissue sections selected among the patients in our hospital for NLRP3, caspase-1, GSDMD, and IL-1β by IHC to examine their expression in Grade 1 (8/15), Grade 2 (3/15), and Grade 3 (4/15) endometrial cancer, atypical hyperplasia (n = 3), and benign endometrial tissues (n = 6). Here, CASP1 is linked to endometrial cancer.