AKT1 and cancer: The pathways with downregulated expression of DEmRNAs included the JAK‐STAT signaling pathway and MAPK signaling pathway, which were previously found to be associated with malignant tumors.34, 35, 36, 37, 43 The PI3K‐Akt signaling pathway has been shown to participate in cell proliferation, migration, differentiation, survival, and trafficking in vitro.44