SFRP2 and osteosarcoma: TET1 plays a crucial role in the DNA methylation process and gene activation.30 Research of Duan H et al have shown that TET1 inhibits EMT of osteosarcoma cells through activating Wnt/β‐catenin signalling inhibitors DKK1 and SFRP2.31 Our findings revealed that EVs circ‐0000190 has the ability to modulate TET1 levels by competitively binding to miR‐767‐5p.