Here, using RNAseq data from patients from TCGA (226 grade II, 240 grade III and 161 grade IV gliomas), we found that WNT6‐high expression increases with glioma grading (Fig. 1A), independently of IDH mutation or 1p/19q codeletion status [12 IDH‐wildtype (IDHwt), 75 IDH‐mutant (IDHmut) non‐co‐deleted, and 47 IDHmut codeleted grade II; 43 IDHwt, 62 IDHmut non‐co‐deleted, and 37 IDHmut codeleted grade III; and 143 IDHwt and 9 IDHmut GBM]. This evidence concerns the gene WNT6 and central nervous system cancer.