Univariate analysis of OS identified three prognostic parameters: sex (p = 0.033), adjuvant chemotherapy (p = 0.036), and OLFM4 expression (p = 0.035), whereas multivariate analysis using Cox proportional hazards showed that adjuvant chemotherapy (p = 0.028) and OLFM4 expression (p = 0.044) were independent prognostic factors of poor outcomes in patients with pancreatic cancer. This evidence concerns the gene OLFM4 and pancreatic neoplasm.