We then analyzed the role of olfactomedin-4 (OLFM4), which was identified as a chemoresistance-related protein, in chemoresistance in an in vitro model and evaluated the expression and prognostic ability of OLFM4 by immunohistochemical (IHC) analysis in 80 pancreatic cancer tissues from human patients. This evidence concerns the gene OLFM4 and pancreatic neoplasm.