KCs showed distinct dysregulation (mostly downregulation) of various metabolic pathways (sugar, protein, fatty acids, hormones, drug, xenobiotics etc.), while DETCs presented with alterations in TGF-β-, Hippo-, oxidative phosphorylation-, citrate cycle-, lipid metabolism-, Staphylococcus aureus infection- etc. pathways (Fig 2D). This evidence concerns the gene TBCE and staphylococcus aureus infection.