Although loss of BECN1 is purported to be solely a passenger mutation "piggybacking" on a BRCA1 deletion during tumorigenesis [12], we directly observed formation of earlier ovarian tumors in Becn1+/- MISIIR-TAg+ mice compared to Becn1+/+ MISIIR-TAg+ mice. Here, BRCA1 is linked to ovarian neoplasm.