EGFR and malignant colon neoplasm: Our previous studies have shown a close relationship between PSTI and the EGF-receptor; the pro-migratory effects of PSTI is inhibited by an EGFR-neutralizing antibody [13], deletion of EGFR prevents the promigratory activity of PSTI in human colon cancer cells and phosphorylation of EGFR occurs in response to PSTI [12].