Then, analysis of different subpopulations of tumor infiltrating lymphocytes (TILs) by using biomarkers such as CD3 (pan T‐cell), CD8 (cytotoxic T‐cell), FoxP3 (regulatory T‐cell), and CD45RO (memory T‐cell) may help to identify predictive T‐cell signatures for immunotherapy. This evidence concerns the gene FOXP3 and neoplasm.