The shift from oxidative phosphorylation to anaerobic glycolysis in response to hypoxia is mediated by the production of HIF.11, 35 Early studies in renal and breast cancer cells have demonstrated that increased phospholipase D is required for the expression of HIF‐1 and HIF‐2, and aerobic glycolysis in these cells is dependent on elevated phospholipase D activity.36, 37, 38 In addition, some other pathways such as focal adhesion, autophagy and AGE‐RAGE with high enrichment may also be involved in hypoxic cancer biology. The gene discussed is HIF1A; the disease is cancer.