In pancreatic ductal adenocarcinoma (PDA), the necroptotic pathway was found to promote oncogenesis through releasing the chemokine (C-X-C motif) ligand 1 (CXCL1) and 130 kDa Sin3-associated polypeptide (SAP-130), which induce immune-suppression in the tumor microenvironment [52]. Here, SAP130 is linked to Patent ductus arteriosus.