MLKL and neoplasm: Interestingly, the depletion of CD8+ T cells only partially reduced the difference of tumor metastasis between wild tpe and MLKL knock out tumor in the MVT-1 model (unpublished data), indicating that, in addition to inhibiting the anti-tumor activity of T cells, necroptosis likely modulates other aspects of the tumor microenvironment to promote metastasis.