The objective of this work was to characterize the effects of diet‐induced obesity starting in childhood on the later PINS anatomy and control of pancreatic endocrine function in a well‐described mouse model of diet‐induced obesity, characterized by hyperinsulinaemia and impaired glucose tolerance.31 We used a new model of ex vivo pancreas culture, in which we demonstrated a dose‐dependent insulin secretion in response to glucose consistent with a preserved pancreatic function. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.