ZEB1 and renal cell carcinoma: However, a newly identified mechanism of IFIT5 is regulation of the turnover of tumor suppressor microRNAs (miRNAs), including miR-363 and miR-128, resulting in increased expression of transcription factors of EMT such as slug and ZEB1, thereby enhancing invasion in renal cell carcinoma (RCC) (Lo et al., 2019).