Multiple genetic studies have since validated the association of PNPLA3(148M) with a broad spectrum of liver diseases ranging from ALD and NAFLD, non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) (33, 66–117). The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatohepatitis.