In addition to those environmental factors, numerous genetic variants have been shown to be associated with ALD and NAFLD, including patatin-like phospholipase domain-containing protein 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), glucokinase regulator (GCKR), membrane bound O-acyltransferase domain-containing 7 (MBOAT7), and hydroxysteriod 17-beta dehydrogenase 13 (HSD17B13) (7, 8). The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.