Interestingly, HIF-1α has also been shown to support cancer related lymphangiogenesis by upregulating the expression and subsequent secretion of Ang1/2, VEGF-C/D and PDGF-B from neoplastic cells into the tumor stroma, in several cancers as breast cancer, esophageal cancer, and oral squamous carcinoma (96–98). This evidence concerns the gene VEGFC and neoplasm.