BCL2 and breast cancer: Notably, Bcl-2 family members were shown to interact with Drp1 and treatment with BH3-mimetic A-1210477 led to Drp1-dependent mitochondria fragmentation, whereas Drp1 silencing significantly reduced apoptosis induced by BH3-mimetic in lung, cervical, and breast cancer cell lines (Milani et al., 2018).