EZH2 and cancer: In the past few years, enhancer of zeste homolog 2 (EZH2), the catalytic subunit of Polycomb repressive complex 2 (PRC2), has aroused broad research interest because of its multiple roles in the development of many types of cancer (Margueron and Reinberg, 2011; Di Croce and Helin, 2013; Comet et al., 2016; Kim and Roberts, 2016).