Although mutation of some genes, such as BRAF, NRAS, and TP53, have been identified as risk factors for melanoma progression (Byron et al., 2012; Posch et al., 2013; Lissanu Deribe et al., 2016; Hayward et al., 2017; Ojha et al., 2019), our knowledge of molecular mechanism underlying the malignant melanoma remains obscure. This evidence concerns the gene TP53 and melanoma.