In melanoma, lncRNA SAMMSON increases its mitochondrial targeting and pro-oncogenic function by interacting with p32, a master regulator of mitochondrial homeostasis and metabolism (Leucci et al., 2016), lncRNA SLNCR1 mediates melanoma invasion through a highly conserved sequence binding to brain-specific homeobox protein 3a (Brn3a) and the androgen receptor (AR). The gene discussed is LINC00511; the disease is melanoma.