ERBB2 and neoplasm: And finally, besides clinical factors such as tumor size, lymph node involvement, and clinical stage, the prognostic value of histo-pathological aspects such as tumor type and grade, and molecular subtypes (luminal A, luminal B, HER2-enriched, and basal-like) is conserved between canine and human breast cancer (Rivera et al., 2009; Queiroga et al., 2011b; Sleeckx et al., 2011; Lahkhani et al., 2012; Rasotto et al., 2012, 2017; Im et al., 2013; Pena et al., 2013; Nguyen et al., 2017).