Likewise, expression of VEGFR-2, the main signaling VEGF receptor in vascular endothelial cells, in endothelial cells within the tumor tissue increased with malignancy, histological grade, and lymph node metastases, implicating VEGF and VEGFR-2 in angiogenesis in CMTs (Restucci et al., 2004; Diessler et al., 2016; Anjos Dos et al., 2019). This evidence concerns the gene KDR and neoplasm.