TIMP2 and cancer: One report found expression of TIMP-2 to decrease in tumor tissue compared to controls, and also to decrease from grade I to grade III tumors (Vinothini et al., 2009), while Aresu et al. (2011) did not find statistically significant differences in TIMP-2 (nor TIMP-1, TIMP-3, or RECK) levels between benign and malignant tumors.