In addition, BMP-1 expression is modulated by mutations in both alpha procollagen chains (Lindahl et al., 2011) and BMP-1-knockout mice develop an osteogenesis imperfecta-like phenotype due to inefficient procollagen processing and bone mineralization (Figure 9B; Muir et al., 2014). This evidence concerns the gene BMP1 and osteogenesis imperfecta.