For example, oncogenic gene translocation and consequent juxtaposition of the c-MYC gene with enhancer elements has been reported in multiple myeloma, which may enhance c-MYC expression (Shou et al., 2000), and aberrant expression of the HOXA cluster of TFs has been reported in several aggressive acute leukemias as a result of oncogenic rearrangements of the MLL1 gene, a histone methyltransferase (Kawagoe et al., 1999; Guenther et al., 2005). Here, MYC is linked to acute leukemia.