LDLR and atherosclerosis: In the vasculature, endothelial knock-down of FoxO1, FoxO3 and FoxO4 appears to be protective against atherosclerosis in LDLr–/– mice, a transgenic mouse model that creates a pro-atherogenic environment due to a lack of low-density lipoprotein receptors (LDLr) (Tsuchiya et al., 2012).