Though SNAI1/Snail and SNAI2/Slug are considered to play the same biological role in EMT triggering in epithelial tumors (Lamouille et al., 2014), it has been shown for melanoma cells that SNAI2/Slug is responsible for melanocytic differentiation and thus suppresses EMT (Caramel et al., 2013). The gene discussed is SNAI2; the disease is melanoma.