SNCA and Parkinson disease: Indeed, a few naturally occurring mutations of residues belonging to the α-synuclein AH (Pozo Devoto et al., 2017) are associated with Parkinson’s disease: Ala30Pro (Krüger et al., 1998), Glu46Lys (Zarranz et al., 2004), His50Gln (Appel-Cresswell et al., 2013), Gly51Asp (Kiely et al., 2013; Lesage et al., 2013), Ala53Thr (Polymeropoulos et al., 1997), and Ala53Glu (Pasanen et al., 2014).