VEGFA and neoplasm: On the other hand, inducing maturation of tumor vessels, for instance by inhibition of the VEGF signaling cascade, was reported to improve delivery of small and intermediately sized nanoparticles up to 40 nm to tumor tissue (Chauhan et al., 2012; Jiang et al., 2015) due to a reduction in the interstitial pressure and consequent dominance of convection over the less efficient diffusion (see next section).