Results in Figure 5B showed that IL-1β treated OC-C exhibited significantly greater fold change of MMP1, 2, 3, 9, 13, ADAMTS4, 5, IL-1β, and IL-6 than CH tissue, when the expression levels of these genes were normalized to their own control (without the treatment of IL-1β). This evidence concerns the gene ADAMTS4 and cyclic hematopoiesis.