Chakravarthi et al. (2018) reported that ETS-related gene (ERS) specifically targets and activates FZD8 directly by binding to its promoter region rather than ETV1 and suggested that the overexpression of ERG in PCa leads to FZD8 induction and the activation of the Wnt pathway (Chakravarthi et al., 2018). The gene discussed is FZD8; the disease is posterior cortical atrophy.