FZD8 and posterior cortical atrophy: This research group also found that the silencing of FZD8 suppressed the migration and invasion of cells and the occurrence of PCa bone metastasis in vitro and in vivo by activating the canonical β-catenin/Wnt signaling pathway, and the data suggest that FZD8 could be a potential therapeutic target for the treatment of bone metastasis in PCa (Li et al., 2017).