The research group led by He et al. recently found that miR-520b overexpression results in the inhibition of cell proliferation, migration, and invasion in human spinal osteosarcoma (OS) tissues and cell lines by inactivating the Wnt/β-catenin signaling pathway through the downregulation of FZD8 and thus provides a new spinal OS therapeutic target (Wang et al., 2017). Here, FZD8 is linked to osteosarcoma.