Dings et al. worked continuously on modifications and mechanism of calix[4]arene-based anti-tumor agents, identified galectin-1 (gal-1) as the molecular target, and explored compounds PTX008, PTX013 as potent anti-tumor agents (Figure 1) (Dings et al., 2012a,b, 2013; Koonce et al., 2017). Here, LGALS1 is linked to neoplasm.