The major neuropathological hallmarks of AD are the aggregation of two proteins, amyloid-β (Aβ) and tau, with the first forming aggregates (oligomers and plaques) in the extracellular environment of the brain, and the latter forming neurofibrillary tangles (NFTs) in neurons due to hyperphosphorylation and oxidative modifications of tau (Um et al., 2013). The gene discussed is MAPT; the disease is Alzheimer disease.