Moreover, Gallart-Palau et al. (45) examined the extent of gender-specific molecular differences in developing Alzheimer's disease with cerebrovascular disease and found that despite the presence of a similar amount of brain protein (i.e., myelin-associated glycoprotein) in men and women, women than men were more likely to receive a stronger influence from the pathology of white matter. Here, MAG is linked to early-onset autosomal dominant Alzheimer disease.