AQP4 and systemic lupus erythematosus: Anti-AQP4 seropositive status is more often identified in female pediatric patients (3:1); it may be related to a relapsing–remitting course of the disease and could also be related with other systemic autoimmune disorders, like Sjogren syndrome, systemic lupus erythematosus (SLE), thyroid diseases, and myasthenia gravis (28).