IRF4 and asthma: There were 25 novel childhood-onset asthma loci detected, in or near biologically important genes such as NOD2, IL4R, IL2RA, and IRF4. Because the UKBB dataset is generally available, we can contrast these findings to those published by Zhu et al. (26) who reported a total of 38 loci for “doctor diagnosed” asthma detectable using an earlier available version of the dataset containing 7908 cases and 76768 controls, and Johansson et al. (24) who reported 52 loci defined via 41934 cases and 239773 controls (Figure 2).