If we take one of the functional 17q21 SNPs rs12936231 (actually within ZPBP2), in the UK BioBank the C allele increases “all” asthma OR = 1.1 (P = 1 × 10−59) and self-reported “emphysema/chronic bronchitis” OR = 1.07 (P = 1 × 10−8, but not doctor-diagnosed emphysema, P = 0.5), as well as neutrophil count (P = 7 × 10−142), but less strongly with eosinophil count (P = 3 × 10−5) (32). This evidence concerns the gene ZPBP2 and pulmonary emphysema.