The authors found that genes reported previously to interact with tobacco smoke exposure with respect to asthma development (i.e., GSTP1, TNF and ADAM33) were not among the most significant hits and showed suggestive interactions between rs8094633 near erythrocyte membrane protein band 4.1 like 3 (EPB41L3) and exposure to in utero tobacco smoke, and between rs1575472 in parkin coregulated gene (PACRG) and childhood ETS. The gene discussed is TNF; the disease is asthma.