SIX1 and thyroid cancer, nonmedullary, 2: However, a significant increase in SIX1 and EYA1 was detected in malignant tumor, including FTC (p = 0.011, p = 0.038; respectively), MTC (p = 0.006, p = 0.043; respectively), PTC (p < 0.001, p < 0.001; respectively) and ATC samples (p = 0.002, p < 0.001; respectively) (Figure 1A).