Heat shock proteins showed the most significant change of all the upregulated domains, with Hsp90AA1, Hsp90AB1, TRAP1, HspA5, HspB1, HspE1, HspD1, HspA1B, HspA8, HspA9, and HspA4 identified in breast cancer tissue (Table S3). Here, HSPA5 is linked to breast cancer.