In GBM with IDH-wildtype, Kaplan-Meier analysis showed that patients in the high-risk group (n = 53) had a lower OS than patients in the low-risk group (n = 52) in the training cohort (median OS = 8.47 vs. 17.13 months; P < 0.0001; Figure 3A). Here, IDH1 is linked to glioblastoma.