TNF and glioma: Moreover, KEGG pathway analysis showed that positively-related genes in the high-risk group were primarily enriched in biological processes for “TNF signaling pathway,” “cytokine-cytokine receptor interaction,” “leukocyte transendothelial migration,” “toll-like receptor signaling pathway,” and “chemokine signaling pathway,” whereas the negatively correlated genes were enriched in biological terms including “GABAergic synapse,” “Rap1 signaling pathway,” and “glioma” (Figure 5B).