Moreover, KEGG pathway analysis showed that positively-related genes in the high-risk group were primarily enriched in biological processes for “TNF signaling pathway,” “cytokine-cytokine receptor interaction,” “leukocyte transendothelial migration,” “toll-like receptor signaling pathway,” and “chemokine signaling pathway,” whereas the negatively correlated genes were enriched in biological terms including “GABAergic synapse,” “Rap1 signaling pathway,” and “glioma” (Figure 5B). The gene discussed is TNF; the disease is central nervous system cancer.