MSH2 and Lynch syndrome: On the other hand, the genes with pathogenic variants associated with other syndromes included the Fanconi Anemia FANCM, Lynch syndrome MLH3, MSH2, MSH6; the colorectal adenoma MUTYH, the pancreatic and melanoma CDKN2A; and the ataxia telangiectasia gene ATM, as previously reported (15, 34–37).