Pathogenic variants in non-BRCA genes were found in 12 genes, including those in other high and moderate HBOC risk genes such as MSH2, MSH6, MUTYH, and PALB2. The hereditary melanoma and pancreatic cancer gene CDKN2A was found mutated in one patient from Mexico. This evidence concerns the gene MSH2 and familial pancreatic carcinoma.