Pathogenic variants in non-BRCA genes were found in 12 genes, including those in other high and moderate HBOC risk genes such as MSH2, MSH6, MUTYH, and PALB2. The hereditary melanoma and pancreatic cancer gene CDKN2A was found mutated in one patient from Mexico. The gene discussed is CDKN2A; the disease is pancreatic neoplasm.