GOLPH3 and ductal breast carcinoma in situ: In the present study, immunohistochemical techniques were applied to evaluate the role of GOLPH3 in carcinoma cells and FAP-a in the stroma in recruited DCIS patients received combined treatment of wide-excision and close follow-up, but haven't received any type of chemo- or radio-therapy; which further explored the potentials of FAP-a and GOLPH3 as indicative marker during the natural progression of DCIS.