In accordance to our expectation, the integral transcriptional expression level of ACAT1, BDH2, and HMGCL all prominently descended in ccRCC in compare with normal groups (ACAT1: SMD = −1.89, 95% CI = −2.35 to −1.43; BDH2: SMD = −1.78, 95% CI = −2.27 to −1.28; HMGCL: SMD = −1.60, 95% CI = −2.25 to −0.95). The gene discussed is ACAT1; the disease is nonpapillary renal cell carcinoma.