BDH2 and nonpapillary renal cell carcinoma: We found that ACAT1 and BDH2 overexpressing 786-0 cells invaded the extracellular matrix gel to a much lower extent than the control cells (Figure 6C) and that the gap closure in the transfected cells was slower (Figure 6D), indicating a role of the restored ACAT1 and BDH2 expression in attenuation of the metastatic processes in ccRCC disease.