NFATC2 and acute lymphoblastic leukemia: Another study performed in several cohorts of ALL childhood patients (for a total of 3,308 children) found that the intronic SNP rs6021191 harbored by the nuclear factor of activated T cells 2 (nfatc2) gene displayed the strongest association with HR (57), whereas the gria1 rs4958351 variant did not achieve the significance threshold of GWAS (p = 5 × 10−8).