The hdac6, a member of the histone deacetylase (HDAC), is involved in the pathogenesis of lymphoma, as demonstrated both in vitro (promotion of cell proliferation) and in vivo (xenograft growth), it is upregulated in FFPE samples from DLBCL and it decreases the HR23B-mediated degradation of MET (45). This evidence concerns the gene HDAC6 and diffuse large B-cell lymphoma.