In glioblastoma, the role of miR-28-5p has not yet been fully explored, but its structurally related miR-708 was demonstrated to inhibit glioblastoma cell proliferation by targeting EZH2, AKT1, MMP2, CCND1, Parp-1, and Bcl-2 (58). The gene discussed is EZH2; the disease is glioblastoma.