TRPM7 and central nervous system cancer: The results indicated that the inhibition of TRPM7 expression by siTRPM7 markedly reduced Rap1b expression at both mRNA (Figures 4C,D, upper right) and protein levels (Figure 4D, left and lower right); while the overexpression of TRPM7 dramatically enhanced the expression of Rap1b at both mRNA (Figure 4E) and protein levels (Figure 4F) in all four glioma cell lines.