As expected, the reduction of Rap1b expression by siRap1b effectively reduced glioma cell proliferation induced by miR-28-5p inhibitor during 24 to 96 h post-transfection by a maximum of 52, 41.8, and 69.2% for A172, U87MG, and U373MG at 96 h, 60% for SNB19 at 48 h (Figure 6C). The gene discussed is RAP1B; the disease is central nervous system cancer.