RAP1B and central nervous system cancer: Our data revealed that miR-28-5p was inversely regulated by TRPM7 expression in glioma cells; overexpression of miR-28-5p significantly inhibited glioma cell growth, migration, and invasion; the gene encoding Ras-related protein Rap1b, positively correlated with TRPM7, is a promising candidate target gene of miR-28-5p and may serve as a predictive marker for the poor survival of glioma patients (14, 15).