Kir et al. identified tumor-derived PTHrP as an inducer of WAT browning in a rodent cancer model and reported that approximately one third of patients with metastatic non-small-cell lung cancer (NSCLC) or colorectal cancer had detectable serum PTHrP, together with higher REE and lower lean body mass, compared to PTHrP-negative patients (34, 38–40). Here, PTHLH is linked to colorectal cancer.