Leukemia stem cell quiescence: Activation of PPARγ by endogenous prostaglandin J2 mediates the antileukemic effect of selenium in murine leukemia. Selenium-dependent activation of PPARγ, mediated by endogenous CyPGs decreased Stat5 expression leading to the downregulation of Cited2, a master regulator of LSC quiescence. Here, CITED2 is linked to leukemia.