AKT1 and endometrium neoplasm: Meanwhile, loss-of-function mutation of METTL14 in endometrial tumor also diminishes m6A methylation, inhibits YTHDF1-mediated translation of PHLPP2, and impedes YTHDF2-related mRNA decay of mTORC2, both of which regulate AKT pathway, as aforementioned in METTL3 (53).