Similarly, in pancreatic cancer, WTAP promotes cell migration, invasion, and chemoresistance to gemcitabine via stabilizing focal adhesion kinase (Fak) mRNA and subsequently activating Fak-PI3K-AKT and Fak-Src-GRB2-Erk1/2 pathways (57). This evidence concerns the gene PTK2 and familial pancreatic carcinoma.