SENP1 and neoplasm: The colibactin genotoxin produced by Escherichia coli promotes cellular senescence by the upregulation of miR-20a-5p, which in turn downregulates SENP1, resulting in the proliferation of uninfected cells and, subsequently, tumor growth. The over-expression of miR-20a-5p also alters p53 SUMOylation, which has been shown to promote tumor growth and metastasis