METTL3 and cancer: In addition, METTL3-mediated m6A modification can directly regulate the transcription and translation of oncogenes and tumor suppressors coupled to the most of the important pathways involved in cancer cell progression, such as the PI3K/AKT (36, 44, 47, 57, 60, 62), wnt/β-catenin (46), and P38/ERK (26) pathways.