In addition, METTL3-mediated m6A modification can directly regulate the transcription and translation of oncogenes and tumor suppressors coupled to the most of the important pathways involved in cancer cell progression, such as the PI3K/AKT (36, 44, 47, 57, 60, 62), wnt/β-catenin (46), and P38/ERK (26) pathways. This evidence concerns the gene METTL3 and neoplasm.