In addition, METTL3-mediated m6A modification can directly regulate the transcription and translation of oncogenes and tumor suppressors coupled to the most of the important pathways involved in cancer cell progression, such as the PI3K/AKT (36, 44, 47, 57, 60, 62), wnt/β-catenin (46), and P38/ERK (26) pathways. The gene discussed is AKT1; the disease is cancer.