Wei et al. showed that nuclear METTL3 increases the Bax/Bcl2 ratio in lung cancer cells and that METTL3 knockdown strongly increases the levels of cleaved caspase3 and PARP, implying that knockdown of METTL3 induces the mitochondrial apoptotic pathways in lung cancer cells (36). Here, BCL2 is linked to lung carcinoma.