Angiogenesis is implicated in RCC tumorigenesis with a multiple involved factor, including VHL, HIF-1α, VEGF, PDGF, and PI3K/PKB/mTOR (Phosphoinositide 3-kinases/Protein Kinase B) signaling (1, 4–7, 9). The gene discussed is HIF1A; the disease is renal cell carcinoma.