Decreased expression of VEGF and MMP-9 in medulloblastoma cells that overexpress osteonectin, also referred to as Secreted Protein Acidic and Rich in Cysteine (SPARC), leads to decreased angiogenesis and tumor growth, indicating the pro-angiogenic role of MMP-9 in cancer tissues (129). The gene discussed is MMP9; the disease is medulloblastoma.