Transfected cells A549 overexpressing IL-37 cause low gene expression of MMT-9, PCNA, Ki-67, Cyclin D1 and CDK4, but elevated expression of caspace-3 and caspace-9. IL-37 inhibits the proliferation, migration and invasion of human lung adenocarcinoma A549 cells as well as the chemotaxis of Treg cells and promotes apoptosis of A549 cells. Here, CCND1 is linked to lung adenocarcinoma.