Stage II colorectal cancer. Poor prognosis is associated with low expression of the genes PIGR, CXCL13, MMP3, TUBA1B, CXCL10, and high expression of SESN1, AZGP1, KLK6, EPHA7, SEMA3A, DSC3 ENPP3, BNIP3 and ENPP3. This evidence concerns the gene KLK6 and colorectal cancer.