IL-35 can induce N2 neutrophil polarization (protumor phenotype) by increasing G-CSF and IL-6 production, and promote Neutrophil infiltration into tumor microenvironment. IL-35 stimulated macrophages to secrete proinflammatory cytokines IL-1β, IL-6 and up-regulate the expression of MMP-9, suggesting antitumoral activity. The gene discussed is MMP9; the disease is neoplasm.