CHI3L1 promotes the metastasis of gastric and breast cancer cells, interacts with the IL-13Rα receptor on the plasma membrane of gastric cancer cells. Even more, CHI3L1 activates MAPK signaling pathway in gastric and breast cancers and the activator protein-1 (AP) transcriptional activity in cancer cells. This evidence concerns the gene DHCR7-DT and breast carcinoma.