Aberrant TNF-α signaling promotes cancer cell motility, invasiveness, and enhances cancer metastasis mediated NF-kB signaling. TNF-α-induced expression and stabilization of C/EBPb depends on p38MAPK activation, but not on NF-kB activity. C/EBPβ and its downstream MMP-1 and MMP-3 are required for TNF-α-induced cancer cell migration. TNF-α activates multiple signaling pathways, including NF-kB and C/EBPβ to promote cancer cell migration. TNF-α treatment significantly increased the number of migrated MDA-MB-231 and MDA-MB-435 cells in a dose-dependent manner. This evidence concerns the gene MMP1 and cancer.