Additionally, cross-talk between MMP-7 and MMP-9 leads to the cleavage of insulin-like growth factor-binding protein 2 (IGFBP-2), an angiogenic activator in major aggressive cancers via the transcriptional regulation of the VEGF gene, showing adverse effects in cancer angiogenesis in some tissues (139, 140). The gene discussed is MMP9; the disease is cancer.