MALAT1 and breast carcinoma: By utilizing subcutaneous injections of lncRNA MALAT1 translational oligonucleotides to treat breast cancer in mice, the Gayatri Arun team found that the suppression of MALAT1 by antisense oligonucleotides significantly inhibited the growth of mouse breast cancer and promoted tumor transition from solid nodules to cystic components; this approach could inhibit the invasion and migration ability of tumor cells in vitro in 3D-like organ cultures (16, 18).