The BC susceptibility locus CCL5 rs2107538 in our cohort was significantly associated with the risk for both TNBC and HRBC; the other breast cancer susceptibility locus rs2280789 was associated with an increased risk for TNBC but only had a marginal effect on HRBC, while rs2280788 had a weak association with TNBC risk. Here, CCL5 is linked to breast cancer.