The sh-SMAD5-AS1 group showed reduced tumor volume vs. the sh-NC group (p < 0.05), which was in line with the reduction shown in the miR-195 mimic group and the sh-SMAD5 group when compared with the mimic NC group and the sh-NC group, respectively (all p < 0.05). This evidence concerns the gene SMAD5 and neoplasm.